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The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

29 Apr 2020

Abstract excerpt

Natural killer (NK) cells are important in the immune defense against tumor cells and pathogens, and they regulate other immune cells by cytokine secretion. Although murine NK cell biology has been extensively studied, knowledge about transcriptional circuitries controlling human NK cell development and maturation is limited. By generating ETS1-deficient human embryonic stem cells and by expressing the...

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PMID: 32350509
DOI: 10.1182/blood.2020005204

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