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Article

Genome-based classification of pancreatic acinar cell carcinoma reveals similarities to KRAS wild-type PDAC.

Journal of translational medicine - 24 Dec 2025

Liu Mengyuan, Seier Kenneth, Gonen Mithat, Sigel Carlie, Jung Joslyn, Blair Alex B, Howell Thomas C, Reidy-Lagunes Diane, Lidsky Michael E, Allen Peter J, Blazer Iii Dan G, Zani Sabino, Wei Alice C, Drebin Jeffrey A, Balachandran Vinod, D'Angelica Michael, Soares Kevin C, Kingham T Peter, Jarnagin William R

Abstract excerpt

BACKGROUND: Pancreatic acinar cell carcinoma (ACC) is a rare primary neoplasm of acinar cell origin. Histologically, it can present as pure ACC or mixed with neuroendocrine or ductal differentiation. We studied whether ACC shared genomic similarities with pancreatic ductal adenocarcinoma (PDAC) or well-differentiated pancreatic neuroendocrine tumors (PNET) using the hidden genome classifier methodology. METHODS:...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41444605
DOI: 10.1186/s12967-025-07381-7
PMCID: PMC12729626

Genes

KRAS
ATRX
SETD2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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