Article
Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas.
Scientific reports - 6 Mar 2015
Furukawa Toru, Sakamoto Hitomi, Takeuchi Shoko, Ameri Mitra, Kuboki Yuko, Yamamoto Toshiyuki, Hatori Takashi, Yamamoto Masakazu, Sugiyama Masanori, Ohike Nobuyuki, Yamaguchi Hiroshi, Shimizu Michio, Shibata Noriyuki, Shimizu Kyoko, Shiratori Keiko
Abstract excerpt
Acinar cell carcinoma of the pancreas is a rare tumor with a poor prognosis. Compared to pancreatic ductal adenocarcinoma, its molecular features are poorly known. We studied a total of 11 acinar cell carcinomas, including 3 by exome and 4 by target sequencing. Exome sequencing revealed 65 nonsynonymous mutations and 22 indels with a mutation rate of 3.4 mutations/Mb per tumor, on average. By accounting for not...
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