Article
Whole-exome sequencing of pancreatic neoplasms with acinar differentiation.
The Journal of pathology - 1 Mar 2014
Jiao Yuchen, Yonescu Raluca, Offerhaus G Johan A, Klimstra David S, Maitra Anirban, Eshleman James R, Herman James G, Poh Weijie, Pelosof Lorraine, Wolfgang Christopher L, Vogelstein Bert, Kinzler Kenneth W, Hruban Ralph H, Papadopoulos Nickolas, Wood Laura D
Abstract excerpt
Pancreatic carcinomas with acinar differentiation, including acinar cell carcinoma, pancreatoblastoma and carcinomas with mixed differentiation, are distinct pancreatic neoplasms with poor prognosis. Although recent whole-exome sequencing analyses have defined the somatic mutations that characterize the other major neoplasms of the pancreas, the molecular alterations underlying pancreatic carcinomas with acinar...
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