Article
An integrative gene network-based approach to uncover the cellular and molecular infrastructures of schizophrenia.
Life sciences - 1 Nov 2020
Bozorgmehr Ali, Sadeghi Bahman, Tabatabaei Zavari Elmira Sadat, Bahrami Elnaz, Zamani Fariba, Shahbazi Ali
Abstract excerpt
AIMS: High phenotypic and endophenotypic heritability of schizophrenia indicates substantial involvement of genetic elements in the occurrence of this disorder. Multiplicity of hypotheses about the genetic basis of schizophrenia pathogenesis suggests that there is still no integrated image from cellular and molecular infrastructure of this disorder. MATERIALS AND METHODS: Here, we aimed to gain an integrated...
Topics
- Biomarkers
- Gene Expression Regulation
- Gene Regulatory Networks
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Polymorphism, Single Nucleotide
- Schizophrenia