Article
Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation.
Schizophrenia bulletin - 7 Mar 2024
van der Meer Dennis, Cheng Weiqiu, Rokicki Jaroslav, Fernandez-Cabello Sara, Shadrin Alexey, Smeland Olav B, Ehrhart Friederike, Gülöksüz Sinan, Pries Lotta-Katrin, Lin Bochao, Rutten Bart P F, van Os Jim, O'Donovan Michael, Richards Alexander L, Steen Nils Eiel, Djurovic Srdjan, Westlye Lars T, Andreassen Ole A, Kaufmann Tobias
Abstract excerpt
BACKGROUND: Schizophrenia is a highly heritable brain disorder with a typical symptom onset in early adulthood. The 2-hit hypothesis posits that schizophrenia results from differential early neurodevelopment, predisposing an individual, followed by a disruption of later brain maturational processes that trigger the onset of symptoms. STUDY DESIGN: We applied hierarchical clustering to transcription levels of 345...
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