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Article

Integrative eQTL-weighted hierarchical Cox models for SNP-set based time-to-event association studies.

Journal of translational medicine - 9 Oct 2021

Lu Haojie, Wei Yongyue, Jiang Zhou, Zhang Jinhui, Wang Ting, Huang Shuiping, Zeng Ping

Abstract excerpt

BACKGROUND: Integrating functional annotations into SNP-set association studies has been proven a powerful analysis strategy. Statistical methods for such integration have been developed for continuous and binary phenotypes; however, the SNP-set integrative approaches for time-to-event or survival outcomes are lacking. METHODS: We here propose IEHC, an integrative eQTL (expression quantitative trait loci)...

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PMID: 34627275
DOI: 10.1186/s12967-021-03090-z
PMCID: PMC8502405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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