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Article

A new efficient method to detect genetic interactions for lung cancer GWAS.

BMC medical genomics - 30 Oct 2020

Luyapan Jennifer, Ji Xuemei, Li Siting, Xiao Xiangjun, Zhu Dakai, Duell Eric J, Christiani David C, Schabath Matthew B, Arnold Susanne M, Zienolddiny Shanbeh, Brunnström Hans, Melander Olle, Thornquist Mark D, MacKenzie Todd A, Amos Christopher I, Gui Jiang

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have proven successful in predicting genetic risk of disease using single-locus models; however, identifying single nucleotide polymorphism (SNP) interactions at the genome-wide scale is limited due to computational and statistical challenges. We addressed the computational burden encountered when detecting SNP interactions for survival analysis, such as age of...

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Identifiers

PMID: 33126877
DOI: 10.1186/s12920-020-00807-9
PMCID: PMC7596958

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BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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