Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Jagged1 (JAG1): Structure, expression, and disease associations.

Gene - 15 Jan 2016

Grochowski Christopher M, Loomes Kathleen M, Spinner Nancy B

Abstract excerpt

Jagged1 (JAG1) is one of the 5 cell surface ligands that functions primarily in the highly conserved Notch signaling pathway. Notch signaling plays a critical role in cellular fate determination and is active throughout development and across many organ systems. The classic JAG1-NOTCH interaction leads to a cascade of proteolytic cleavages resulting in the NOTCH intracellular domain being transported into the...

Topics

Join the communities discussing this publication.

Alagille Syndrome
Calcium-Binding Proteins
Gene Knockdown Techniques
Intercellular Signaling Peptides and Proteins
Jagged-1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serrate-Jagged Proteins

Tetralogy of Fallot

Source

Open in PubMed Open full text

Identifiers

PMID: 26548814
DOI: 10.1016/j.gene.2015.10.065
PMCID: PMC4673022

Genes

JAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Jagged1 (JAG1): Structure, expression, and disease associations.PMID 26548814Read ↗

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1.Semantic proximity Read ↗

Alagille syndrome and the Jagged1 gene.Semantic proximity Read ↗

Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndromeSemantic proximity Read ↗

Identification of 36 novel Jagged1 (JAG1) mutations in patients with Alagille syndrome.Semantic proximity Read ↗

Alagille syndrome mutation update: Comprehensive overview ofJAG1andNOTCH2mutation frequencies and insight into missense variant classificationSemantic proximity Read ↗

Clinical and molecular genetics of Alagille syndrome.Semantic proximity Read ↗

Familial Tetralogy of Fallot caused by mutation in the jagged1 gene.Semantic proximity Read ↗

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway.Semantic proximity Read ↗

The Notch ligand Jagged1 as a target for anti-tumor therapySemantic proximity Read ↗

Spectrum of JAG1 gene mutations in Polish patients with Alagille syndrome.Semantic proximity Read ↗

Spectrum and frequency of jagged1 (JAG1) mutations in Alagille syndrome patients and their families.Semantic proximity Read ↗

Mutations in the human Jagged1 gene are responsible for Alagille syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.