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Article

Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer

15 Nov 2018

Abstract excerpt

Aberrant Notch signaling is implicated in several cancers, including breast cancer. However, the mechanistic details of the specific receptors and function of ligand-mediated Notch signaling that promote breast cancer remains elusive. In our studies we show that DLL1, a Notch signaling ligand, is significantly overexpressed in ERα + luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor...

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PMID: 30442981
DOI: 10.1038/s41388-018-0562-z

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