JAK-STAT pathway in hematological malignancies: achievements, challenges and future perspectives

Abstract excerpt

Over the past few decades, the JAK-STAT signaling pathway has emerged as a focal point in the fields of cell biology and pathology. This pathway is considered one of the central communication nodes in cellular function, playing a crucial role in pro-cesses such as cell proliferation, differentiation, survival, and apoptosis. It also me-diates immune dysregulation and tumor development. Dysregulated JAK-STAT sig-na...

Topics

Open a Topic to create a Post that cites this publication.

• Chronic Myeloid Leukemia Treatments
• Cytokine Signaling Pathways and Interactions
• Hematologic Neoplasms
• Janus Kinase 2
• Mutation
• Myeloproliferative Neoplasms: Diagnosis and Treatment
• Signal Transduction
• STAT Transcription Factors

Identifiers and source

Literature Corpus work

c0ae27cb-a24b-5764-922d-834499a4e57a

DOI

10.22541/au.174386356.66413924/v1