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Mutation profile of acute myeloid leukaemia in a Chinese cohort by targeted next-generation sequencing.

Cancer reports (Hoboken, N.J.) - 1 Oct 2022

Lit Benny Man Wai, Guo Belinda B, Malherbe Jacques A J, Kwong Yok Lam, Erber Wendy N

Abstract excerpt

BACKGROUND: Acute myeloid leukaemia (AML) results from the clonal expansion of blast cells of myeloid origin driven by genomic defects. The advances in next-generation sequencing (NGS) have allowed the identification of many mutated genes important in the pathogenesis of AML. AIMS: In this study, we aimed to assess the mutation types and frequency in a Chinese cohort presenting with de novo AML cohort using a...

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PMID: 34617422
DOI: 10.1002/cnr2.1573
PMCID: PMC9575498

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