Article
SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.
Gastroenterology - 1 Nov 2016
Wong Chi Chun, Qian Yun, Li Xiaona, Xu Jiaying, Kang Wei, Tong Joanna H, To Ka-Fai, Jin Ye, Li Weilin, Chen Huarong, Go Minnie Y Y, Wu Jian-Lin, Cheng Ka Wing, Ng Simon S M, Sung Joseph J Y, Cai Zongwei, Yu Jun
Abstract excerpt
BACKGROUND & AIMS: Many colorectal cancer (CRC) cells contain mutations in KRAS. Analyses of CRC cells with mutations in APC or CTNNB1 and KRAS identified SLC25A22, which encodes mitochondrial glutamate transporter, as a synthetic lethal gene. We investigated the functions of SLC25A22 in CRC cells with mutations in KRAS. METHODS: We measured levels of SLC25A22 messenger RNA and protein in paired tumor and...
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