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Article

Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses.

Journal of cellular biochemistry - 1 Apr 2011

Mooney Steven M, Rajagopalan Krithika, Williams Brenten H, Zeng Yu, Christudass Christhunesa S, Li Youqiang, Yin Bo, Kulkarni Prakash, Getzenberg Robert H

Abstract excerpt

Creatine kinase brain (CKB) is one of three cytosolic isoforms of creatine kinase that is predominantly expressed in the brain. The enzyme is overexpressed in a wide variety of cancers, with the exception of colon cancer, where it is downregulated. The significance of this downregulation remains poorly understood. Here, we demonstrate that overexpression of CKB-C283S, a dominant-negative construct that lacks the...

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Identifiers

PMID: 21308735
DOI: 10.1002/jcb.23020
PMCID: PMC4380256

Genes

CKB
CFP
PAGE4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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