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Article

Race-Dependent Association of Single-Nucleotide Polymorphisms in TrkB Receptor in People Living with HIV and Depression.

Neurotoxicity research - 1 Dec 2021

Avdoshina Valeria, Yumoto Futoshi, Mocchetti Italo, Letendre Scott L, Tractenberg Rochelle E

Abstract excerpt

Human immunodeficiency virus (HIV)-associated cognitive disorders (HAND) is characterized by impaired motor and intellectual functions, as well as mood disorders. Brain-derived neurotrophic factor and its receptor TrkB (or NTRK2) mediate the efficacy of antidepressant drugs. Genomic studies of BDNF/TrkB have implicated common single-nucleotide polymorphisms in the pathology of depression. In the current study, we...

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Identifiers

PMID: 34613587
DOI: 10.1007/s12640-021-00406-1
PMCID: PMC10880801

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Race-Dependent Association of Single-Nucleotide Polymorphisms in TrkB Receptor in People Living with HIV and Depression.PMID 34613587Read ↗

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