Article
Single-nucleotide polymorphisms in TrkB and risk for depression: findings from the women's interagency HIV study.
Journal of acquired immune deficiency syndromes (1999) - 1 Oct 2013
Avdoshina Valeriya, Mocchetti Italo, Liu Chenglong, Young Mary A, Anastos Kathryn, Cohen Mardge, Crystal Howard, Pearce Celeste L, Golub Elizabeth T, Tractenberg Rochelle E
Abstract excerpt
Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 (rs2072446) were...
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