Article
Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence.
Neuroscience letters - 10 Apr 2009
Lohoff Falk W, Bloch Paul J, Ferraro Thomas N, Berrettini Wade H, Pettinati Helen M, Dackis Charles A, O'Brien Charles P, Kampman Kyle M, Oslin David W
Abstract excerpt
Cocaine-induced neuroplasticity changes in the mesocorticolimbic dopamine systems are thought to be involved in the pathophysiology of cocaine dependence. Since neurotrophic factors have been observed to prevent/reverse and mimic cocaine-induced neurobiological changes in the brain, related genes are plausible candidates for susceptibility to cocaine dependence. The novel conserved dopamine neurotrophic factor...
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