Article
Implications of a highly divergent dengue virus strain for cross-neutralization, protection, and vaccine immunity.
Cell host & microbe - 10 Nov 2021
Chen Rita E, Smith Brittany K, Errico John M, Gordon David N, Winkler Emma S, VanBlargan Laura A, Desai Chandni, Handley Scott A, Dowd Kimberly A, Amaro-Carambot Emerito, Cardosa M Jane, Sariol Carlos A, Kallas Esper G, Sékaly Rafick-Pierre, Vasilakis Nikos, Fremont Daved H, Whitehead Stephen S, Pierson Theodore C, Diamond Michael S
Abstract excerpt
Although divergent dengue viruses (DENVs) have been isolated in insects, nonhuman primates, and humans, their relationships to the four canonical serotypes (DENV 1-4) are poorly understood. One virus isolated from a dengue patient, DKE-121, falls between genotype and serotype levels of sequence divergence to DENV-4. To examine its antigenic relationship to DENV-4, we assessed serum neutralizing and protective...
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