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Antigenic evolution of dengue viruses over 20 years

18 Nov 2021

Abstract excerpt

Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcγ receptor–bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944...

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PMID: 34793238
DOI: 10.1126/science.abk0058

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