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Article

Development of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain.

Applied microbiology and biotechnology - 1 Dec 2023

Tabata Koshiro, Itakura Yukari, Ariizumi Takuma, Igarashi Manabu, Kobayashi Hiroko, Intaruck Kittiya, Kishimoto Mai, Kobayashi Shintaro, Hall William W, Sasaki Michihito, Sawa Hirofumi, Orba Yasuko

Abstract excerpt

The most conserved fusion loop (FL) domain present in the flavivirus envelope protein has been reported as a dominant epitope for cross-reactive antibodies to mosquito-borne flaviviruses (MBFVs). As a result, establishing accurate serodiagnosis for MBFV infections has been difficult as anti-FL antibodies are induced by both natural infection and following vaccination. In this study, we modified the most conserved...

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Source

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Identifiers

PMID: 37831184
DOI: 10.1007/s00253-023-12817-5
PMCID: PMC10656323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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