Article
Super-Resolution Whole-Brain 3D MR Spectroscopic Imaging for Mapping D-2-Hydroxyglutarate and Tumor Metabolism in Isocitrate Dehydrogenase 1-mutated Human Gliomas.
Radiology - 1 Mar 2020
Li Xianqi, Strasser Bernhard, Jafari-Khouzani Kourosh, Thapa Bijaya, Small Julia, Cahill Daniel P, Dietrich Jorg, Batchelor Tracy T, Andronesi Ovidiu C
Abstract excerpt
Background Isocitrate dehydrogenase (IDH) mutations are highly frequent in glioma, producing high levels of the oncometabolite D-2-hydroxyglutarate (D-2HG). Hence, D-2HG represents a valuable imaging marker for IDH-mutated human glioma. Purpose To develop and evaluate a super-resolution three-dimensional (3D) MR spectroscopic imaging strategy to map D-2HG and tumor metabolism in IDH-mutated human glioma....
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