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Article

Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation.

The Journal of biological chemistry - 1 May 2009

Zhou Xiangdong, Agazie Yehenew M

Abstract excerpt

The Src homology phosphotyrosyl phosphatase 2 (SHP2) plays a positive role in HER2-induced signaling and transformation, but its mechanism of action is poorly understood. Given the significance of HER2 in breast cancer, defining a mechanism for SHP2 in the HER2 signaling pathway is of paramount importance. In the current report we show that SHP2 positively modulates the Ras-extracellular signal-regulated kinase 1...

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Identifiers

PMID: 19261604
DOI: 10.1074/jbc.M900020200
PMCID: PMC2673291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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