Article
Whole-genome sequencing for surveillance of tuberculosis drug resistance and determination of resistance level in China.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 May 2022
Liu Dongxin, Huang Fei, Zhang Guoliang, He Wencong, Ou Xichao, He Ping, Zhao Bing, Zhu Baoli, Liu Fei, Li Zhiyuan, Liu Chunfa, Xia Hui, Wang Shengfen, Zhou Yang, Walker Timothy M, Liu Lei, Crook Derrick W, Zhao Yanlin
Abstract excerpt
OBJECTIVES: Phenotypic drug susceptibility testing for prediction of tuberculosis (TB) drug resistance is slow and unreliable, limiting individualized therapy and monitoring of national TB data. Our study evaluated whole-genome sequencing (WGS) for its predictive accuracy, use in TB drug-resistance surveillance and ability to quantify the effects of resistance-associated mutations on MICs of anti-TB drugs....
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