Article
Use of whole-genome sequencing to predict Mycobacterium tuberculosis drug resistance in Indonesia.
Journal of global antimicrobial resistance - 1 Mar 2019
Chaidir Lidya, Ruesen Carolien, Dutilh Bas E, Ganiem Ahmad R, Andryani Anggriani, Apriani Lika, Huynen Martijn A, Ruslami Rovina, Hill Philip C, van Crevel Reinout, Alisjahbana Bachti
Abstract excerpt
OBJECTIVES: Whole-genome sequencing (WGS) is rarely used for drug resistance testing of Mycobacterium tuberculosis in high-endemic settings. Here we present the first study from Indonesia, which has the third highest tuberculosis (TB) burden worldwide, with <50% of drug-resistant cases currently detected. METHODS: WGS was applied for strains from 322 human immunodeficiency virus (HIV)-negative adult TB patients....
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