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First insight of characteristics and prediction of Mycobacterium tuberculosis drug resistance by whole genome sequencing in Fujian Province, China.

Scientific reports - 16 Feb 2026

Wei Shuzhen, Zhao Yong, Lin Jian, Lin Shufang, Dai Zhisong, Lin Yongming, Deng Yanqin

Abstract excerpt

To delineate the molecular characteristics and assess the drug resistance prediction value of whole-genome sequencing (WGS) for Mycobacterium tuberculosis (MTB) in Fujian Province, China. Representative MTB surveillance isolates underwent phenotypic drug susceptibility testing (pDST), followed by WGS(gDST), with resistance mutation analysis conducted on the SAM-TB platform. The rate of mono-resistance,...

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PMID: 41699389
DOI: 10.1038/s41598-026-40398-6
PMCID: PMC13000260

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