Article

Integrating morphology and gene expression of neural cells in unpaired single-cell data using GeoAdvAE

2025-11-19

Abstract excerpt

<h4>Background</h4> Cellular morphological transitions are observed across many diseases, yet their functional role remains unclear because few technologies profile form and function in the same cell. Linking single-cell morphology to transcriptomics is difficult: the two modalities share no feature correspondence and are typically measured in different cells. <h4>Methods</h4> We present GeoAdvAE, a geometry-awa...

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Literature Corpus work: a7f94e64-a3e4-5471-ac79-fffe1c0eb4d5
DOI: 10.1101/2025.11.19.689368

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