Article
Single-cell RNA-sequencing atlas of bovine caudal intervertebral discs: Discovery of heterogeneous cell populations with distinct roles in homeostasis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2021
Panebianco Christopher J, Dave Arpit, Charytonowicz Daniel, Sebra Robert, Iatridis James C
Abstract excerpt
Back and neck pain are significant healthcare burdens that are commonly associated with pathologies of the intervertebral disc (IVD). The poor understanding of the cellular heterogeneity within the IVD makes it difficult to develop regenerative IVD therapies. To address this gap, we developed an atlas of bovine (Bos taurus) caudal IVDs using single-cell RNA-sequencing (scRNA-seq). Unsupervised clustering resolved...
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