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Single-cell atlas unveils cellular heterogeneity and novel markers in human neonatal and adult intervertebral discs

1 Jun 2022

Abstract excerpt

The origin, composition, distribution, and function of cells in the human intervertebral disc (IVD) have not been fully understood. Here, cell atlases of both human neonatal and adult IVDs have been generated and further assessed by gene ontology pathway enrichment, pseudo-time trajectory, histology, and immunofluorescence. Comparison of cell atlases revealed the presence of two subpopulations of notochordal...

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PMID: 35754733
DOI: 10.1016/j.isci.2022.104504

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