Article
Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes.
Arthritis research & therapy - 1 Jan 2010
Minogue Ben M, Richardson Stephen M, Zeef Leo Ah, Freemont Anthony J, Hoyland Judith A
Abstract excerpt
INTRODUCTION: Nucleus pulposus (NP) cells have a phenotype similar to articular cartilage (AC) cells. However, the matrix of the NP is clearly different to that of AC suggesting that specific cell phenotypes exist. The aim of this study was to identify novel genes that could be used to distinguish bovine NP cells from AC and annulus fibrosus (AF) cells, and to further determine their expression in normal and...
Topics
- Animals
- Cartilage, Articular
- Cattle
- Chondrocytes
- Gene Expression
- Gene Expression Profiling
- Humans
- Intervertebral Disc
- Intervertebral Disc Degeneration
- Middle Aged