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Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution

25 Mar 2023

Abstract excerpt

Abstract The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae. Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs, a single‐cell transcriptomic atlas mapping early IVD formation is still lacking. Here, the authors generate a spatiotemporal and single cell‐based transcriptomic atlas of human IVD formation at the embryonic stage and a...

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PMID: 36965031
DOI: 10.1002/advs.202206296

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