Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degeneration

8 Nov 2024

Abstract excerpt

The nucleus pulposus (NP) plays a vital role in intervertebral disc degeneration (IVDD). Previous studies have revealed cellular heterogeneity in NP tissue during IVDD progression. However, the cellular and molecular alterations of diverse cell clusters during IVDD remain to be fully elucidated. NP tissues were isolated from patients with different grades of IVDD undergoing discectomy, and then subjected to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Musculoskeletal pain and rehabilitation
Share to Osteoarthritis Treatment and Mechanisms
Share to Spine and Intervertebral Disc Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39516278
DOI: 10.1038/s41598-024-78675-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degenerationPMID 39516278Read ↗

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular InteractionsSemantic proximity Read ↗

Single-cell sequencing: New insights for intervertebral disc degenerationSemantic proximity Read ↗

Single‐Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration ProgressionSemantic proximity Read ↗

Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progressionSemantic proximity Read ↗

Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degenerationSemantic proximity Read ↗

Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discsSemantic proximity Read ↗

Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc DegenerationSemantic proximity Read ↗

Changes in nucleus pulposus cell atlas and the role of SPP1 during intervertebral disc degeneration: Single-cell sequencing analysisSemantic proximity Read ↗

Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc DegenerationSemantic proximity Read ↗

Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cellsSemantic proximity Read ↗

Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degenerationSemantic proximity Read ↗

Single-Cell and WGCNA Integrative Analysis Reveal the Key Chondrocytes Niches and Pathogenic Genes in Intervertebral Disc DegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.