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Article

A locally closed conformation of a bacterial pentameric proton-gated ion channel.

Nature structural & molecular biology - 13 May 2012

Prevost Marie S, Sauguet Ludovic, Nury Hugues, Van Renterghem Catherine, Huon Christèle, Poitevin Frederic, Baaden Marc, Delarue Marc, Corringer Pierre-Jean

Abstract excerpt

Pentameric ligand-gated ion channels mediate signal transduction through conformational transitions between closed-pore and open-pore states. To stabilize a closed conformation of GLIC, a bacterial proton-gated homolog from Gloeobacter violaceus whose open structure is known, we separately generated either four cross-links or two single mutations. We found all six mutants to be in the same 'locally closed'...

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PMID: 22580559
DOI: 10.1038/nsmb.2307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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