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Article

SPOP mutation induces DNA methylation via stabilizing GLP/G9a.

Nature communications - 29 Sept 2021

Zhang Jianong, Gao Kun, Xie Hongyan, Wang Dejie, Zhang Pingzhao, Wei Ting, Yan Yuqian, Pan Yunqian, Ye Wenbin, Chen Huifen, Shi Qing, Li Yao, Zhao Shi-Min, Hou Xiaonan, Weroha Saravut J, Wang Yuzhuo, Zhang Jun, Karnes R Jeffrey, He Housheng Hansen, Wang Liguo, Wang Chenji, Huang Haojie

Abstract excerpt

Mutations in SPOP E3 ligase gene are reportedly associated with genome-wide DNA hypermethylation in prostate cancer (PCa) although the underlying mechanisms remain elusive. Here, we demonstrate that SPOP binds and promotes polyubiquitination and degradation of histone methyltransferase and DNMT interactor GLP. SPOP mutation induces stabilization of GLP and its partner protein G9a and aberrant upregulation of...

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Identifiers

PMID: 34588438
DOI: 10.1038/s41467-021-25951-3
PMCID: PMC8481544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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