Article
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.
Nature genetics - 20 May 2012
Barbieri Christopher E, Baca Sylvan C, Lawrence Michael S, Demichelis Francesca, Blattner Mirjam, Theurillat Jean-Philippe, White Thomas A, Stojanov Petar, Van Allen Eliezer, Stransky Nicolas, Nickerson Elizabeth, Chae Sung-Suk, Boysen Gunther, Auclair Daniel, Onofrio Robert C, Park Kyung, Kitabayashi Naoki, MacDonald Theresa Y, Sheikh Karen, Vuong Terry, Guiducci Candace, Cibulskis Kristian, Sivachenko Andrey, Carter Scott L, Saksena Gordon, Voet Douglas, Hussain Wasay M, Ramos Alex H, Winckler Wendy, Redman Michelle C, Ardlie Kristin, Tewari Ashutosh K, Mosquera Juan Miguel, Rupp Niels, Wild Peter J, Moch Holger, Morrissey Colm, Nelson Peter S, Kantoff Philip W, Gabriel Stacey B, Golub Todd R, Meyerson Matthew, Lander Eric S, Getz Gad, Rubin Mark A, Garraway Levi A
Abstract excerpt
Prostate cancer is the second most common cancer in men worldwide and causes over 250,000 deaths each year. Overtreatment of indolent disease also results in significant morbidity. Common genetic alterations in prostate cancer include losses of NKX3.1 (8p21) and PTEN (10q23), gains of AR (the androgen receptor gene) and fusion of ETS family transcription factor genes with androgen-responsive promoters. Recurrent...
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