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Article

Divergent functions of IL-17-family cytokines in DSS colitis: Insights from a naturally-occurring human mutation in IL-17F.

Cytokine - 1 Dec 2021

Zhou Chunsheng, Wu Dongwen, Jawale Chetan, Li Yang, Biswas Partha S, McGeachy Mandy J, Gaffen Sarah L

Abstract excerpt

The IL-17 family is structurally distinct from other cytokine subclasses. IL-17A and IL-17F, the most closely related of this family, form homodimers and an IL-17AF heterodimer. While IL-17A and IL-17F exhibit similar activities in many settings, in others their functions are divergent. To better understand the function of IL-17F in vivo, we created mice harboring a mutation in Il17f originally described in...

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Identifiers

PMID: 34587561
DOI: 10.1016/j.cyto.2021.155715
PMCID: PMC8627693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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