Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

30 Jan 2017

Abstract excerpt

Donor T-cell-derived interleukin-17A (IL-17A) can mediate late immunopathology in graft-versus-host disease (GVHD), however protective roles remain unclear. Using multiple cytokine and cytokine receptor subunit knockout mice, we demonstrate that stem cell transplant recipients lacking the ability to generate or signal IL-17 develop intestinal hyper-acute GVHD. This protective effect is restricted to the molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child Nutrition and Feeding Issues
Share to Clinical Nutrition and Gastroenterology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28137828
DOI: 10.1182/blood-2016-08-732628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiomePMID 28137828Read ↗

Divergent functions of IL-17-family cytokines in DSS colitis: Insights from a naturally-occurring human mutation in IL-17F.Semantic proximity Read ↗

Donor-derived IL-17A and IL-17F deficiency triggers Th1 allo-responses and increases gut leakage during acute GVHD.Semantic proximity Read ↗

Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type miceSemantic proximity Read ↗

Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and CancerSemantic proximity Read ↗

Antibody blockade of IL-17 family cytokines in immunity to acute murine oral mucosal candidiasis.Semantic proximity Read ↗

A loss-of-function mutation in IL-17F enhances susceptibility of mice to oropharyngeal candidiasisSemantic proximity Read ↗

Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived ProductsSemantic proximity Read ↗

Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C.Semantic proximity Read ↗

Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells.Semantic proximity Read ↗

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestineSemantic proximity Read ↗

Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infectionSemantic proximity Read ↗

Immunity to infection in IL ‐17‐deficient mice and humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.