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Article

Donor-derived IL-17A and IL-17F deficiency triggers Th1 allo-responses and increases gut leakage during acute GVHD.

PloS one - 1 Jan 2020

Odak Ivan, Depkat-Jakob Alina, Beck Maleen, Jarek Michael, Yu Yan, Seidler Ursula, David Sascha, Ganser Arnold, Förster Reinhold, Prinz Immo, Koenecke Christian

Abstract excerpt

IL-17A and IL-17F cytokines are important regulators of acute graft-versus-host-disease (GVHD). However, contrary effects of these cytokines in inflammatory diseases have been reported. To investigate the effects of donor-derived IL-17A and IL-17F on GVHD, we made use of single (Il17a-/- or Il17f-/-) and double deficient (Il17af-/-) allogeneic donor CD4+ T cells. We could demonstrate that transplantation of...

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Identifiers

PMID: 32251446
DOI: 10.1371/journal.pone.0231222
PMCID: PMC7135231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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