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IL-17 in the Pathogenesis of Disease: Good Intentions Gone Awry

13 Feb 2021

Abstract excerpt

The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include the shared IL-17RA subunit, which is widely expressed throughout the body on both hematopoietic and nonhematopoietic cells. The founding family member, IL-17A, is usually referred to as IL-17 and has received the most attention for...

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PMID: 33577346
DOI: 10.1146/annurev-immunol-101819-092536

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