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Article

A more accurate method for colocalisation analysis allowing for multiple causal variants.

PLoS genetics - 1 Sept 2021

Wallace Chris

Abstract excerpt

In genome-wide association studies (GWAS) it is now common to search for, and find, multiple causal variants located in close proximity. It has also become standard to ask whether different traits share the same causal variants, but one of the popular methods to answer this question, coloc, makes the simplifying assumption that only a single causal variant exists for any given trait in any genomic region. Here,...

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Identifiers

PMID: 34587156
DOI: 10.1371/journal.pgen.1009440
PMCID: PMC8504726

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