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Article

Pharmacogenomics of celiprolol - evidence for a role of P-glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics.

Clinical and translational science - 1 Feb 2022

Hirvensalo Päivi, Tornio Aleksi, Tapaninen Tuija, Paile-Hyvärinen Maria, Neuvonen Mikko, Backman Janne T, Niemi Mikko

Abstract excerpt

The aim of this study was to search for associations of genetic variants with celiprolol pharmacokinetics in a large set of pharmacokinetic genes, and, more specifically, in a set of previously identified candidate genes ABCB1, SLCO1A2, and SLCO2B1. To this end, we determined celiprolol single-dose (200 mg) pharmacokinetics and sequenced 379 pharmacokinetic genes in 195 healthy volunteers. Analysis with 46,064...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34585840
DOI: 10.1111/cts.13159
PMCID: PMC8841435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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