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Article

Atorvastatin population pharmacokinetics in a real-life setting: Influence of genetic polymorphisms and association with clinical response.

Clinical and translational science - 1 Mar 2022

Stillemans Gabriel, Paquot Adrien, Muccioli Giulio G, Hoste Emilia, Panin Nadtha, Åsberg Anders, Balligand Jean-Luc, Haufroid Vincent, Elens Laure

Abstract excerpt

The purpose of this study was to investigate the potential clinical relevance of estimating the apparent clearance (CL/F) of atorvastatin through population pharmacokinetic (PopPK) modeling with samples collected in a real-life setting in a cohort of ambulatory patients at risk of cardiovascular disease by using an opportunistic sampling strategy easily accessible in clinical routine. A total of 132...

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Identifiers

PMID: 34761521
DOI: 10.1111/cts.13185
PMCID: PMC8932751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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