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SLCO1B1 and ABCG2 genotype-informed phenotypes are related to variation in ramipril exposure.

Basic & clinical pharmacology & toxicology - 1 Sept 2024

Abbes Houwaida, Zubiaur Pablo, Soria-Chacartegui Paula, de la Torre Tamara, Villapalos-García Gonzalo, Candau Carmen, Rodríguez-Lopez Andrea, González-Iglesias Eva, Aldama Marina, Navares-Gomez Marcos, Omezzine Asma, Ochoa Dolores, Abad-Santos Francisco

Abstract excerpt

Ramipril is an angiotensin-converting enzyme inhibitor used for hypertension and heart failure management. To date, scarce literature is available on pharmacogenetic associations affecting ramipril. The goal of this study was to investigate the effect of 120 genetic variants in 34 pharmacogenes (i.e., genes encoding for enzymes like CYPs or UGTs and transporters like ABC or SLC) on ramipril pharmacokinetic...

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PMID: 39011815
DOI: 10.1111/bcpt.14046

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