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Article

Identification of Genetic Variants Associated with Pravastatin and Pitavastatin Pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Jun 2025

Mykkänen Anssi J H, Tarkiainen E Katriina, Taskinen Suvi, Neuvonen Mikko, Paile-Hyvärinen Maria, Lilius Tuomas O, Tapaninen Tuija, Backman Janne T, Tornio Aleksi, Niemi Mikko

Abstract excerpt

A clinical trial was carried out to investigate the pharmacogenetics of single-dose pravastatin and pitavastatin pharmacokinetics in 173 and 164 healthy participants. Additionally, 96 participants were included from previous pharmacogenetic studies with pravastatin. In a genome-wide meta-analysis of pravastatin including all 269 participants, SLCO1B1 c.521T>C (rs4149056) was associated with increased AUC0-∞...

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Area Under Curve
Cytochrome P-450 CYP2C9
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Liver-Specific Organic Anion Transporter 1

Source

Identifiers

PMID: 40029062
DOI: 10.1002/cpt.3623

Genes

SLCO1B1
CYP2C9

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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