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Article

Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.

Journal of human genetics - 1 Aug 2012

Endo Seiko, Fukahori Aiko, Tokuhiro Shinya, Shinagawa Akira, Walker Joseph, Yoshihara Kazutaka, Ishizuka Hitoshi, Ieiri Ichiro, Sugiyama Yuichi

Abstract excerpt

It has been reported that organic anion-transporting polypeptide (OATP) 1B1, OATP1B3 and multidrug resistance-associated protein 2 are involved in the hepatobiliary transport of olmesartan. We investigated the association of SLCO1B1, SLCO1B3 and ABCC2 polymorphisms with the pharmacokinetics of olmesartan. We sequenced all exons, exon-intron junctions and the 5' and 3' flanking regions of the three genes in 115...

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PMID: 22695893
DOI: 10.1038/jhg.2012.63

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ABCC2

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Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.PMID 22695893Read ↗

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