Article
Amplicon Remodeling and Genomic Mutations Drive Population Dynamics after Segmental Amplification.
Molecular biology and evolution - 7 Jan 2022
Morgenthaler Andrew B, Fritts Ryan K, Copley Shelley D
Abstract excerpt
New enzymes often evolve by duplication and divergence of genes encoding enzymes with promiscuous activities that have become important in the face of environmental opportunities or challenges. Amplifications that increase the copy number of the gene under selection commonly amplify many surrounding genes. Extra copies of these coamplified genes must be removed, either during or after evolution of a new enzyme....
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