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Article

Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation.

Nature ecology & evolution - 1 May 2018

Rodriguez-Beltran Jeronimo, Hernandez-Beltran J Carlos R, DelaFuente Javier, Escudero Jose A, Fuentes-Hernandez Ayari, MacLean R Craig, Peña-Miller Rafael, San Millan Alvaro

Abstract excerpt

Understanding the mechanisms governing innovation is a central element of evolutionary theory. Novel traits usually arise through mutations in existing genes, but trade-offs between new and ancestral protein functions are pervasive and constrain the evolution of innovation. Classical models posit that evolutionary innovation circumvents the constraints imposed by trade-offs through genetic amplifications, which...

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Identifiers

PMID: 29632354
DOI: 10.1038/s41559-018-0529-z
PMCID: PMC6055991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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