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Revealing the Mutation Patterns of Drug-Resistant Reverse Transcriptase Variants of Human Immunodeficiency Virus through Proteochemometric Modeling.

Biomolecules - 2 Sept 2021

Qiu Jingxuan, Tian Xinxin, Liu Jiangru, Qin Yulong, Zhu Junjie, Xu Dongpo, Qiu Tianyi

Abstract excerpt

Drug-resistant cases of human immunodeficiency virus (HIV) nucleoside reverse transcriptase inhibitors (NRTI) are constantly accumulating due to the frequent mutations of the reverse transcriptase (RT). Predicting the potential drug resistance of HIV-1 NRTIs could provide instructions for the proper clinical use of available drugs. In this study, a novel proteochemometric (PCM) model was constructed to predict...

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Identifiers

PMID: 34572515
DOI: 10.3390/biom11091302
PMCID: PMC8467226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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