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Article

Prediction and molecular field view of drug resistance in HIV-1 protease mutants.

Scientific reports - 21 Feb 2022

Wang Baifan, He Yinwu, Wen Xin, Xi Zhen

Abstract excerpt

Conquering the mutational drug resistance is a great challenge in anti-HIV drug development and therapy. Quantitatively predicting the mutational drug resistance in molecular level and elucidating the three dimensional structure-resistance relationships for anti-HIV drug targets will help to improve the understanding of the drug resistance mechanism and aid the design of resistance evading inhibitors. Here the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35190671
DOI: 10.1038/s41598-022-07012-x
PMCID: PMC8861105

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