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Article

Proteochemometric modeling of HIV protease susceptibility

10 Apr 2008

Abstract excerpt

BACKGROUND: A major obstacle in treatment of HIV is the ability of the virus to mutate rapidly into drug-resistant variants. A method for predicting the susceptibility of mutated HIV strains to antiviral agents would provide substantial clinical benefit as well as facilitate the development of new candidate drugs. Therefore, we used proteochemometrics to model the susceptibility of HIV to protease inhibitors in...

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PMID: 18402661
DOI: 10.1186/1471-2105-9-181

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