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Article

Significantly improved HIV inhibitor efficacy prediction employing proteochemometric models generated from antivirogram data.

PLoS computational biology - 1 Jan 2013

van Westen Gerard J P, Hendriks Alwin, Wegner Jörg K, Ijzerman Adriaan P, van Vlijmen Herman W T, Bender Andreas

Abstract excerpt

Infection with HIV cannot currently be cured; however it can be controlled by combination treatment with multiple anti-retroviral drugs. Given different viral genotypes for virtually each individual patient, the question now arises which drug combination to use to achieve effective treatment. With the availability of viral genotypic data and clinical phenotypic data, it has become possible to create computational...

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PMID: 23436985
DOI: 10.1371/journal.pcbi.1002899
PMCID: PMC3578754

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